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Time-dependent reduction in Aβ levels after PMA treatment. Aβ levels were unaffected by 4αPMA. A,Significant reductions in Aβ40 at 6 hr (P6,p < 0.001) were gone by 12 hr (P12). V, Vehicle; P, PMA. Number of animals per group: V6, 6; V12, 6; P6, 11; P12, 12. B,4αPMA (4αP) did not lower cortical Aβ40 levels after 6 hr compared with the active analog PMA (P, p < 0.03). Number of animals per group: V, 6; 4αP, 7;P, 6.
