Fig. 2.

High magnification of aberrant paranodal structures in the CGT mutant animals. A, A paranodal region from a 30-d-old littermate control displays a periaxonal space with regularly arrayed densities known as transverse bands (arrowheads). These structures are prominent features of the junctional complex normally formed between the axolemma and the myelin sheath. B, Transverse bands were not found in age-matched CGT-deficient mice. Lateral loops in both the spinal cord (C) and brain (D) frequently are reversed and face away from the axon. Furthermore, the outer most lamella terminates farther from the node. Ax, Axon; G, glial fibrillary acid protein. Scale bar, 0.1 μm.