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. 1998 Mar 1;18(5):1753–1762. doi: 10.1523/JNEUROSCI.18-05-01753.1998

Fig. 1.

Fig. 1.

Junctional conductance measurements revealed that coupling strength is higher in the untreated neuroblasts than in cells that differentiated in response to either treatments. Untreated and cytokine-treated neuroblasts were cultured for the same length of time (1–7 DIV). A, Recording of macroscopic junctional conductance in a pair of untreated neuroblasts. Command voltage pulses were applied alternately to cells 1 and 2. Currents recorded in the same cell in which the voltage step is applied represent the sum of conductances of junctional (gj) and nonjunctional (gnj) membranes; junctional currents are recorded in the other cell. Calibration bars: horizontal, 1 sec; vertical, 10 mV (V1,V2), 50 pA (I1,I2). B, Histogram of junctional conductance (gj) values obtained in 115 pairs of untreated neuroblasts. The mean value of gj was 11.28 ± 0.7 nS (median, 10 nS). C, Histogram of gjvalues obtained from neuroblasts treated with IL-7 alone (n = 60). Mean gj was 6.51 ± 0.77 nS (median, 5 nS). D, Histogram ofgj obtained in 100 pairs of neuroblasts treated with bFGF(IL-7 and TGFα). Mean gjwas 5.07 ± 0.51 nS (median, 4 nS).