Fig. 5.

Normalized event histograms demonstrate the presence of a population of higher conductance channels in cell pairs treated with IL-7 alone than in untreated neuroblasts or after combined growth factor treatment. The frequency of conductance values obtained in each experiment was normalized by dividing the number of events of each conductance range (5 or 10 pS bins) by the total number of events recorded for each cell pair. A, The normalized event histogram for untreated neuroblasts contains measurements of 1600 events obtained from 11 cell pairs. The Gaussian best fit to these data (solid curve) indicates a single event population with a peak at 55 pS. B, The normalized event histogram from neuroblasts treated with IL-7 contains 2052 event measurements obtained from nine cell pairs; two Gaussian curves are required to fit the data, with peaks at 40 and 165 pS. C, Normalized event histograms from neuroblasts treated with bFGF(IL-7 and TGFα), consisting of 3300 events from 13 cell pairs; as in the untreated cells, a single Gaussian curve best describes the data with a peak at 64 pS.