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. 1998 May 1;18(9):3147–3157. doi: 10.1523/JNEUROSCI.18-09-03147.1998

Fig. 3.

Fig. 3.

Evoked ACh release under repetitive stimulation is potentiated after injection of apRab3-Q80L. A,B, Trains of eight action potentials at 50 Hz were elicited both in control conditions (control) and after stabilization of the inhibition induced by apRab3-Q80L (+ Q80L). In this experiment, the inhibition induced by apRab3-Q80L was 51%, 3 hr after injection. A shows the superposition of two postsynaptic recordings made in these two conditions; they were normalized against the amplitude of the first response in the train. Recording in control condition is denoted by thethick line. Vertical calibration (100% of first response in the train): 485 nS (control, before injection of apRab3-Q80L) and 250 nS (after injection of apRab3-Q80L and stabilization of the inhibition). B, Facilitation was determined for each of the eight stimulations in the train. In this typical experiment from a series of five, the plot shows the averaged facilitation values (mean ± SD; p < 0.001) determined for six trains in the absence or the presence of apRab3-Q80L. C, Effect of apRab3-Q80L on the facilitation observed during a 1.5 sec train of action potentials at 50 Hz. Same presentation as in A. In this experiment, the mean inhibition produced by apRab3-Q80L was 42%. Vertical calibration (100% of first response in the train): 1020 nS (before injection) and 620 nS (after injection).