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. 1998 May 1;18(9):3261–3272. doi: 10.1523/JNEUROSCI.18-09-03261.1998

Fig. 3.

Fig. 3.

ApoE immunoreactivity is present in the brain of GFAP-apoE3 and GFAP-apoE4 mice. GFAP-apoE3 line 37 (A, B) and GFAP-apoE4 line 22 (C, D) mice on a mouse apoE−/− background were immunostained with a goat anti-apoE antibody. There was strong staining of cells, which by morphology appear to be astrocytes in the hippocampus in both P14 (A, C) and adult (B, D) mice. In addition to staining in glial cell bodies and their processes, apoE-IR also appears to be present in the neuropil. Qualitatively similar apoE-IR is seen in cells that appear to be glial in C57Bl6 apoE+/+ mice in both P14 (E) and adult animals (F). ApoE-IR is not observed in the hippocampus of an apoE−/− adult mouse (G). Scale bar, 130 μm.