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. 1998 May 1;18(9):3261–3272. doi: 10.1523/JNEUROSCI.18-09-03261.1998

Fig. 6.

Fig. 6.

Neurite outgrowth from E19 primary hippocampal neurons is increased when neurons are cultured on the surface of GFAP-apoE3-secreting astrocytes. E19 primary hippocampal neurons (C57Bl6) were plated onto confluent astrocyte monolayers derived from the forebrain of P1 GFAP-apoE3 line 2 (C, D), GFAP-apoE4 line 22 (B), or apoE−/− (A) littermate pups. After 44 hr in culture, MAP-2-IR neurites were on average longer in the presence of the apoE3-secreting astrocytes than in the presence of the apoE4 or apoE−/− astrocytes. The increase in neurite outgrowth seen in the presence of apoE3 was blocked by anti-LRP IgG (D). Scale bar, 26 μm.