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4-AP blocked A-type currents in interneurons.A, K+ currents evoked by a step to +20 mV in the presence of increasing concentrations of 4-AP. Note the prominent crossover of currents at >1 mm concentrations.B, Plot of average peak current ± SEM (measured isochronously) as a function of 4-AP concentration for a sample of four neurons. The data were fit with a Langmuir isotherm with 1 mm IC50.
