Fig. 2.

GRGDSP, but not the control peptide GRADSP, interferes with LTP stabilization. A, Same experiments as those illustrated in Figure 1, except that the data (mean ± SEM) for all groups are united in one graph and expressed as the ratio of the percent LTP at the test site divided by the percent LTP recorded simultaneously at the within-slice control site (□: start of infusion 10 min before TBS, n = 6; •: immediately after TBS, n = 4; ▵: 10 min after TBS,n = 5; ▴: >25 min after TBS,n = 10). B, GRGDSP was applied at a higher concentration (2 mm) and earlier, i.e., 20 min before LTP induction at both test and control site in a group of seven slices. C, Control experiments examining the effect of the non-RGD-containing peptide GRADSP (0.5 mm) in a group of seven slices, using the same experimental protocol as inB.