Fig. 7.

Spontaneous EPSCs are mediated by non-NMDA receptors. A–C, Five sets of continuous 2 sec current recordings for each condition were obtained from a GLC voltage-clamped at −46 mV. A, Control saline. B,d-AP5 (50 μm) affected neither the frequency nor the amplitude of the spontaneous EPSCs. C, The addition of CNQX (5 μm) to the d-AP5 solution abolished all spontaneous events. D, The average waveform of the spontaneous EPSCs in control saline (n = 91; thin line) is superimposed on that in the presence of d-AP5 (n = 125; thick line). The decay phase overlapped for both conditions. E, Cumulative amplitude distribution of spontaneous EPSCs was examined in control saline (thin line) and in the presence of d-AP5 (thick line).