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. 1998 Jun 15;18(12):4616–4626. doi: 10.1523/JNEUROSCI.18-12-04616.1998

Fig. 3.

Fig. 3.

Quantitative analyses on the neurogenesis and fate of pioneer neurons in the hippocampus. Data are expressed as the number of labeled cells per section. A,B, Number of calretinin-positive Cajal-Retzius cells (A) in the stratum lacunosum-moleculare and of GABA-positive neurons (B) in the stratum radiatum at different postnatal ages (P0–P21) and in the adult. Solid bars are crude cell counts, whereas hatched barsare values corrected for a factor of cortical growth (see Materials and Methods). C, Laminar distribution of BrdU-positive cells at P0 after a BrdU pulse injection at E10, E11, E12, or E16. Pioneer neurons in the stratum radiatum and stratum lacunosum-moleculare are generated at E10–E12, whereas the far more numerous pyramidal neurons are born later. D, E, Comparison of the numbers of BrdU-positive cells in the stratum lacunosum-moleculare and stratum radiatum in littermates aged P0 and P45 after BrdU injections administered at E10, E11, and E12. Values at P45 are corrected for a factor of cortical growth as in A and B(** indicates p ≤ 0.01; ANOVA, Scheffé’s test).AD, Adult; CALR, calretinin;SLM, stratum lacunosum-moleculare; SO, stratum oriens; SP, stratum pyramidale;SR, stratum radiatum.