Fig. 6.

Gα_q antisense plasmids increase the log IC₅₀ for Oxo-M inhibition of I_K(M). Scatter-plot is shown of the log IC₅₀for each neuron included in the mean dose–response curves in Figure 5. Log IC₅₀ was calculated from the best-fit curve for Oxo-M inhibition of I_K(M) for every neuron recorded with the injected antisense sequences indicated. Horizontal linesrepresent the mean of each group. The Gα_q antisense plasmid C23–16 significantly increased the log IC₅₀compared with uninjected neurons (p < 0.01), Gα₁₁ antisense plasmid injected cells (p < 0.05), and cells injected with the Gα_q antisense plasmid C6–6 (p< 0.05).