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. 1998 Jun 15;18(12):4482–4489. doi: 10.1523/JNEUROSCI.18-12-04482.1998

Fig. 3.

Fig. 3.

Effects of ω-AgTx-IVA on barium currents in wild-type and leaner Purkinje cells. A1, A2, Barium currents before and after application of 100 nm ω-AgTx-IVA. ω-AgTx-IVA blocked 82% of the current in the tgla/+ cell (A1) and 63% in thetgla/tglacell (A2). Note the similarities of the currents resistant to ω-AgTx-IVA in A1 and A2. The current densities of the ω-AgTx-IVA-resistant current were −24.2 pA/pF for the tgla/+ cell and −25.2 pA/pF for thetgla/tglacell. The current remaining after ω-AgTx-IVA block represents non-P-type currents. B1, B2, ω-AgTx-IVA-sensitive currents were derived by subtracting the control and ω-AgTx-IVA traces in A1 and A2. The ω-AgTx-IVA-sensitive current from thetgla/+ cell had a density of −107.1 pA/pF (B1), and that from thetgla/tglacell was −37.5 pA/pF (B2). C, Plot of the peak current density versus time for the cells in A1and A2. Gray circles represent data from the tgla/+ cell in A1, and the black circles were from thetgla/tglacell in A2. D, ω-AgTx-IVA-sensitive currents from B1 and B2 were scaled and superimposed.