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. 1998 Jun 15;18(12):4673–4683. doi: 10.1523/JNEUROSCI.18-12-04673.1998

Fig. 8.

Fig. 8.

Development of endogenous neuronal activity.A, At 15 hr AEL whole-cell recordings reveal small inward currents that exhibit characteristics of single channel activity. B, Inward currents that resemble EPSCs are first observed in neurons at 16 hr AEL. These currents, which can reach 25pA in amplitude, have a rapid onset but slower decay and persist for ∼10–15 msec. C, Endogenous currents that are attributable to the generation and spread of action potentials in neurons are first observed at 17 hr AEL. These currents are relatively large (some exceeding 50 pA), are brief (3–5 msec), and overshoot. ForB and C, three representative examples from three individual neurons are shown. Neurons are voltage-clamped at −60 mV (A, B) and −40 mV (C) in normal whole-cell saline. Calibration:A, 2.5 pA, 40 msec; B, C, 10 pA, 20 msec.