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. 1998 Jun 15;18(12):4439–4450. doi: 10.1523/JNEUROSCI.18-12-04439.1998

Fig. 1.

Fig. 1.

PC12 cells expressing mutant PS-1 exhibit increased sensitivity to apoptosis induced by mitochondrial toxins.A, Untransfected and vector-transfected control PC12 cells lines and lines overexpressing wild-type PS-1 or mutant (L286V) PS-1 were exposed for 24 hr to the indicated concentrations of 3-NP and the percentages of cells with apoptotic nuclei were quantified. Values are the mean and SEM of determinations made in six to eight cultures. **p< 0.01 compared with each of the other values at that concentration of 3-NP (ANOVA with Scheffe’s post hoc test).B, Untransfected and vector-transfected control PC12 cells lines and lines overexpressing wild-type PS-1 or mutant (L286V) PS-1 were exposed to 2 mm 3-NP for the indicated time periods, and the percentages of cells with apoptotic nuclei were quantified. Values are the mean and SEM of determinations made in at least six cultures. **p < 0.01 compared with each of the other values at that time point (ANOVA with Scheffe’spost hoc test). C, Untransfected and vector-transfected control PC12 cells lines and lines overexpressing wild-type PS-1 or mutant (L286V) PS-1 were exposed for 24 hr to saline (Control) or 100 mm malonate and the percentages of cells with apoptotic nuclei were quantified. Values are the mean and SEM of determinations made in six cultures. *p < 0.01 compared with each of the other values (ANOVA with Scheffe’s post hoc test).