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. 1998 Jun 15;18(12):4439–4450. doi: 10.1523/JNEUROSCI.18-12-04439.1998

Fig. 5.

Fig. 5.

Mitochondrial toxins cause decreases in mitochondrial transmembrane potential and energy charge in PC12 cells expressing mutant PS-1, but not in control cell lines. A, B, Indicated cell lines were exposed for 18 hr (A) or the indicated time periods (B) to 2 mm 3-NP, and levels of JC-1 fluorescence were quantified. Values are the mean and SEM of determinations made in six cultures. **p < 0.01 compared with each of the other values (ANOVA with Scheffe’spost hoc test). C, Indicated cell lines were exposed to increasing concentrations of 3-NP for 24 hr and levels of MTT reduction were quantified. Values are the mean and SEM of determinations made in six cultures. *p < 0.05, **p < 0.01 compared with each of the other values at the corresponding 3-NP concentration (ANOVA with Scheffe’spost hoc test). D, Indicated cell lines were exposed to 100 mm malonate for 24 hr and levels of MTT reduction were quantified. Values are the mean and SEM of determinations made in six cultures. **p < 0.01 compared with each of the other values (ANOVA with Scheffe’spost hoc test).