Effects of APC, DEGR-Xa, NM-induced leukocytopenia, and DIP-APC on motor disturbances 1 d after induction of SCI as determined by an inclined-plane test. Motor disturbances of the hindlimbs were evaluated 1 d later using an inclined-plane test. APC (100 μg/kg), DIP-APC (100 μg/kg), DEGR-Xa (10 mg/kg), or buffer (as a control) was administered intravenously 30 min before injury, or APC was administered 30 min after injury. Leukocytes were depleted by administration of nitrogen mustard (NM). Mean ± SD of 10 experiments. *p < 0.05 versusTrauma.