Table 1.
Kinetic parameters for evoked, spontaneous and miniature IPSCs recorded at 35°C and 24°C
| Fast IPSCs | Slow IPSCs | |||||||
|---|---|---|---|---|---|---|---|---|
| tRise | τDec1 | Fast (%) | τDec2 | n | τRise | τDecay | n | |
| Evoked 35°C | 0.72 ± 0.07 | 3.51 ± 0.26 | 46 ± 4 | 13.7 ± 0.6 | 25 | 4.69 ± 0.41 | 50.8 ± 2.5 | 44 |
| Spont. 35°C | 0.43 ± 0.02 | 3.22 ± 0.35 | 48 ± 5 | 12.9 ± 1.1 | 16 (998) | 5.49 ± 0.59 | 41.9 ± 3.0 | 12 (97) |
| Mini 35°C | 0.43 ± 0.02 | 3.68 ± 0.59 | 55 ± 9 | 13.8 ± 1.0 | 7 (492) | 4.83 ± 0.64 | 39.7 ± 4.4 | 3 (15) |
| Evoked 24°C | 1.3 ± 0.2 | 11.2 ± 1.1 | 61 ± 3 | 38.8 ± 3.2 | 10 | 6.84 ± 0.44 | 109.4 ± 5.9 | 21 |
| Spont. 24°C | 0.77 ± 0.06 | 14.4 ± 1.0 | 67 ± 4 | 45.0 ± 4.8 | 6 (379) | 8.95 ± 0.91 | 75.8 ± 2.7 | 4 (42) |
| Mini 24°C | 0.70 ± 0.05 | 13.6 ± 0.8 | 68 ± 4 | 42.9 ± 3.4 | 7 (558) | — | — | — |
Units are in msec. Data are mean ± SEM; n = number of cells. Number of events is indicated in parentheses for spontaneous and miniature IPSCs. For fast IPSCs, 10–90% rise times (tRise), decay time constants (τDec1,2), and the percentage of amplitude contributed by the fast component are shown. For slow IPSCs, rise and decay time constants are shown. In an additional eight cells, the evoked GABAA,fast at 35°C decayed monoexponentially, with τDec = 9.40 ± 0.51 msec. Only two slow mIPSCs were obtained at room temperature and are not included in the table.n differs for fast and slow sIPSCs and mIPSCs because slow events were not observed in every cell.