Fig. 6.

Dendrotoxin-I and α-dendrotoxin block slow current selectively. A, C, Tail currents are shown at the bottom left in control and either dendrotoxin-I (A) or α-dendrotoxin (C). The dotted line shows the steady-state current. The insets show the current during the step in control and dendrotoxin as indicated. Traces are averages of three to four leak-subtracted sweeps. B, D, Summary of changes in the fast and slow tail currents caused by 500 nm DTX-I and 2 μm α-DTX, respectively (n as indicated, and asterisks are as in Fig. 1). Both toxins caused a significant block of both fast and slow components. Also, for both toxins the amount of block did not increase with concentrations >500 nm (data not shown).