Fig. 2.

Hippocampal formation of adult NEX mutant mice.A, B, Nissl staining demonstrates a regular morphology of the hippocampal fields in 30-d-old homozygous mutants (−/−) compared with wild-type controls (+/+).C, D, By immunohistochemical analysis, the transcription factor Krox-24 marks the hippocampal CA1 field and is unaltered. E, F, The regular development of granule cell dendrites and mossy fibers is shown by immunostaining of calbindin-D28k that also labels dendrites and perikarya of CA1 pyramidal neurons. G, H, The presence of normal numbers of interneurons is visualized by immunostaining for parvalbumin.