Fig. 3.
The Bcl-xL transgene is expressed at high levels in the forebrain of line 7194.A, Section through the forebrain of a transgenic mouse hybridized with a probe for Bcl-xL. This probe detects both the endogenous and transgene-derivedBcl-xL. B, Adjacent section from the same brain as in A, hybridized with the SV40 probe, which detects only transgene-derived Bcl-xLmRNA. Note the high levels of transgene expression in the cerebral cortex (arrows) and thalamic nuclei. Also note the high expression in CA1, CA2 and CA4 regions of the hippocampus, and the minimal expression in the dentate and CA3 regions. Scale bar, 1 mm.