Fig. 4.

Total number of Fluorogold-positive cells at 24 or 96 hr (also see Fig. 2) after application of the Fluorogold tracer onto the central nerve stump of the cut sciatic nerve of 29-d-old control and pmn mice. In controls (n = 4) the total number of labeled cells at 24 hr represents 65% of the maximum obtained at 96 hr; in pmn (n = 4) only 30% of the cells are labeled (****p < 0.0001 for both). These results and those presented in Figure 3A,B suggest an impairment in uptake/retrotransport properties in pmn.