Fig. 7.

Restoration of motoneuron retrolabeling rate by BDNF and CNTF but not NGF or GDNF. After section of the sciatic nerve of 29-d-old pmn or control mice, neurotrophic factors (1 μg/μl) mixed with Fluorogold have been applied onto the proximal nerve stump. Twenty-four hours later, the number of labeled motoneurons was determined and expressed as a percentage of the values obtained with Fluorogold alone. The values obtained with CNTF and BDNF were significantly different from those of other groups (one-way ANOVA and Student’s t test; ***p < 0.005; ****p < 0.001). As in Figure 5, none of the factors tested induced any changes in the control animals.