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. 1998 Feb 1;18(3):923–931. doi: 10.1523/JNEUROSCI.18-03-00923.1998

Table 2.

Effects of NO on motor neuron survival

Treatment Motor neuron survival* (%) n
None 35  ± 4 10
BDNF 100  ± 4 10
BDNF + DETA-NONOate 102  ± 7 6
DETA-NONOate 31  ± 4 4
DETA 35  ± 5 4
l-NAME + DETA 79  ± 8 4
l-NAME + DETA-NONOate 50  ± 6 6
l-NAME + DETA-NONOate + SOD 27  ± 4 4
SOD 37  ± 8 4

*The percentage of motor neuron survival was determined 24 hr after plating, as described in Materials and Methods. The number of cells in BDNF-treated cultures at 24 hr was taken as 100%. Values are mean ± SD of n determination from at least two independent experiments. The concentrations were 100 pg/ml BDNF, 20 μm DETA-NONOate; 20 μm DETA; 1 mml-NAME; and 1000 U/ml SOD. Similar results were obtained by using up to 25,000 U/ml SOD.

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