Table 1.

Anticonvulsant activities and neurotoxicities of prototype AEDs in MDDAS and classic animal seizure tests

MDDAS model						Classical animal seizure test models
Drugs	Pharmacological data	Adult OF1 mice	MDDAS	Adult DBA2 mice	MDDAS	Drugs	Pharmacological data	Adult CF1 mice	MES	scPTZ	scBic	scPic
PHT	ED50		24		23	PHT	ED50		9.5	>300	>100	>100
	TD50	70		73			TD50	65
	PI		3.0		3.2		PI		6.9	<0.22	<0.7	<0.7
CBZ	ED50		25		23	CBZ	ED50		8.8	102	100	37
	TD50	90		87			TD50	72
	PI		3.6		3.8		PI		8.1	0.7	0.7	1.9
PB	ED50		13		12	PB	ED50		22	13	38	27
	TD50	76.6		72			TD50	69
	PI		6.1		6.0		PI		3.2	5.2	1.8	2.5
VPA	ED50		70		73	VPA	ED50		272	149	360	387
	TD50	418		440			TD50	426
	PI		6.0		6.0		PI		1.6	2.9	1.2	1.1
ESM	ED50		73		78	ESM	ED50		>1000	130	459	243
	TD50	435		420			TD50	441
	PI		6.0		5.4		PI		<0.44	3.4	1.0	1.8
DZP	ED50		0.09		0.12	DZP	ED50		19.1	0.17	1.2	1.2
	TD50	2.4		2.6			TD50	7.3
	PI		26.7		21.7		PI		0.4	43.0	6.1	6.1

ED₅₀ (dose ensuring an anticonvulsant protection in 50% of tested animals) and TD₅₀ (dose eliciting minimal neurotoxicity signs in 50% of animals submitted to the rotorod test) values are expressed as milligrams per kilogram. PI is equal to the ratio between TD₅₀ and ED₅₀ values. For other determinations on the response of classical convulsant animal models (CF1 mice) to AEDs, see White et al. (1995b).