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Schematic representation and topology relative to the plasma membrane of Cx32, with the approximate location of the CMTX mutations analyzed: two were in the first transmembrane domain (TM1), one in the first extracellular loop (EC1), one in the second transmembrane domain (TM2), three in the middle cytoplasmic region, one in the second extracellular loop (EC2), and three in the C-terminal portion (C).
