Fig. 3.

Expression of CMTX mutations of Cx32 in homotypic oocyte pairs reveals two opposite behaviors. Antisense-treated oocytes (see Materials and Methods) were injected with the specified cRNAs and paired in homotypic configuration for 24–48 hr before junctional conductance was measured by a dual voltage-clamp procedure. Four of the CMTX mutations retained channel-forming activity that was macroscopically indistinguishable from that of Cx32wt. Data were pooled from at least three independent experiments and are presented as the mean ± SEM of the number of pairs indicated for each condition.