Table 4.
Inhibition of transient PKC activation during conditioning does not affect associative olfactory memory
| Conditioning | 1× (CS-US) | 3× (CS-US) | ||
|---|---|---|---|---|
| Injection | PBS | Gö7874 | PBS | Gö 7874 |
| 1 trial | 0.03 (79) | 0.00 (49) | 0.05 (76) | 0.02 (67) |
| 2 trial | — | — | 0.49 (77) | 0.47 (69) |
| 3 trial | — | — | 0.61 (78) | 0.69 (70) |
| 3 hr | 0.46 (38) | 0.51 (40) | 0.74 (43) | 0.83 (40) |
| 18 hr | 0.35 (60) | 0.38 (30) | 0.63 (46) | 0.62 (43) |
| 2 d | 0.52 (52) | 0.52 (35) | 0.75 (38) | 0.65 (38) |
| 3–4 d | 0.52 (44) | 0.45 (29) | 0.79 (24) | 0.63 (32) |
Animals were injected with 1 μl Gö 7874 (1 mm) or PBS and received one [1× (CS-US)] or three forward pairings [3× (CS-US)] 20 min later. The data show the probability of the conditioned PER during the acquisition and at different times after conditioning (the number of animals is shown in parentheses). The values of Gö 7874-injected animals are in no case significantly different from the corresponding values from control animals (PBS) (p > 0.05; χ2test).