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. 1998 Jun 1;18(11):3991–4000. doi: 10.1523/JNEUROSCI.18-11-03991.1998

Fig. 6.

Fig. 6.

Long-term changes in synaptic efficacy and SN structure with 4× applications of 5-HT to different areas of SN–L7 interaction. A, Examples of changes in EPSP evoked before (Pre) and 22 hr after (Post) 4× applications of control solution (Fast Green) to the SN cell body and terminal region (CONT) or 4× application of 5-HT to the terminal region (TERM), SN cell body (CB), or both the cell body and terminal region (CB + TERM). B, Summary of the percentage of change in EPSP amplitude 22 hr after 4× applications of control or experimental treatments. ANOVA (F(3,64) = 31.504; p < 0.001) indicated an overall effect of treatment. Scheffé’sF tests indicated that applications of 5-HT to the cell body alone (CB, n = 16 cultures) evoked significant changes as compared with control (CONT, n = 16 cultures;F = 21.375; p < 0.01) or 5-HT applications to the terminal region alone (TERM,n = 16 cultures; F = 16.653;p < 0.01). Applications of 5-HT to both cell body and terminal region (CB + TERM, n = 20) evoked significant changes as compared with control treatment (F = 13.940; p < 0.01) or 5-HT applications to the terminal region alone (F = 10.124, p < 0.01). C, Summary of the net change in SN varicosities 22 hr after 4× applications of control or experimental treatments for a subset of the cultures examined in B. ANOVA (F(3,32) = 8.377;p < 0.001) indicated an overall effect of treatment. Scheffé’s F tests indicated that only applications of 5-HT to both regions evoked a significant change in the number of SN varicosities as compared with controls (F = 4.177; p < 0.03), 5-HT applications to the SN cell body alone (F = 3.153;p < 0.05), or applications to the terminal region alone (F = 5.733; p < 0.01).