Fig. 6.

Protection by arginase is not mimicked by inhibitors of nitric oxide synthesis. A, The nitric oxide synthase inhibitors l-NMA (100 μm) or GED (100 μm) do not significantly attenuate SV-induced cytotoxicity (assessed 48 hr after infection) in N18 cells, nor do they inhibit the protective effects of recombinant arginase (2.5 μg/ml). Eachbar represents the mean ± SD for three to five experiments performed in triplicate. B, The nitric oxide synthase inhibitor l-NAME (100 or 500 μm) does not significantly attenuate glutathione depletion-induced death in embryonic cortical neurons. Eachbar represents the mean ± SEM for three to five experiments performed in triplicate. An asterisk denotes a statistical difference from control (p < 0.05 by ANOVA).