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DβH and Fos immunoreactivity in the LC.A, DβH immunocytochemistry in the LC of a saline-injected withdrawing rat; B, DβH immunocytochemistry in the LC of a toxin-injected withdrawing rat;C, Fos-LI in the LC of a saline-injected withdrawing rat; and D, Fos-LI in the LC of a toxin-injected withdrawing rat. Note the decrease in DβH immunoreactivity and decrease in Fos-LI in the toxin-treated rats (arrows). Scale bar, 200 μm.
