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. 1998 Oct 15;18(20):8485–8495. doi: 10.1523/JNEUROSCI.18-20-08485.1998

Fig. 7.

Fig. 7.

Nicotine did not enhance EPSPs in the mature neocortex. A, Nicotine (10 μm, 50 msec) did not modify the EPSP in a P20 neuron. Superfusion of CNQX (20 μm) and picrotoxin (10 μm) isolated the late EPSP, which remained unaffected by nicotine (middle trace) and was blocked by APV (50 μm;lower trace). Increasing the stimulus intensity resulted in a larger (11 mV) isolated late EPSP in CNQX and picrotoxin that also was not affected by nicotine (data not shown). Vm, −77 mV. B, Nicotine did not affect EPSPs in P19–24 neurons (n = 18; p values > 0.10). Average Vm, −70.4 ± 1.5 mV.