Fig. 7.

Results of image analysis of TUNEL-labeled nuclei density in neuron layers of the piriform layer II (A) and frontal cortex layers II–III (B). Leupeptin exacerbated and aprotinin protected against Aβ-associated toxicity in both regions.C, Nuclear area per cell labeled with TUNEL in layers II–III of the frontal cortex demonstrates that, in the Aβ40 and Aβ40 plus leupeptin groups, TUNEL labeled a larger area per nucleus. [Counterstaining with hematoxylin shows that TUNEL is labeling an average of 30% of the nuclear area.] Error bars represent SE.