Table 1.
Comparison of the morphological features of CA3C hippocampal pyramidal cell dendrites and axons in control and experimental rats
| Parameters | Apical | Basilar | Total | |||
|---|---|---|---|---|---|---|
| Control | Experimental | Control | Experimental | Control | Experimental | |
| n | 6 | 6 | 6 | 6 | 6 | 6 |
| Dendrites | ||||||
| Spine density (number/100 μm)1-a | 46.2 ± 2.5 | 36.5 ± 5.3** | 49.5 ± 4.7 | 31.6 ± 6.4*** | 47.8 ± 2.8 | 34.0 ± 4.9*** |
| Diameter1-a | ||||||
| Minimal (μm) | 0.40 ± 0.08 | 0.18 ± 0.04*** | 0.37 ± 0.07 | 0.24 ± 0.04** | 0.39 ± 0.07 | 0.22 ± 0.04*** |
| Maximal (μm) | 0.50 ± 0.14 | 0.26 ± 0.06** | 0.43 ± 0.08 | 0.29 ± 0.07** | 0.47 ± 0.11 | 0.28 ± 0.06** |
| Thorny excrescences | ||||||
| Number | 6.50 ± 1.39 | 2.83 ± 1.72** | 6.00 ± 4.14 | 3.83 ± 3.13 | 12.5 ± 4.41 | 6.67 ± 4.32* |
| Area (μm2) | 55.9 ± 31.1 | 73.7 ± 71.8 | 39.0 ± 21.3 | 45.8 ± 39.2 | 50.6 ± 12.1 | 66.4 ± 29.8 |
| Segment number | 75.5 ± 26.1 | 67.8 ± 25.8 | 73.3 ± 16.0 | 51.2 ± 13.4* | 143 ± 35.8 | 124 ± 9.4 |
| Length (mm) | 4.64 ± 1.42 | 4.43 ± 0.76 | 3.96 ± 0.77 | 3.01 ± 0.98 | 8.60 ± 1.63 | 7.45 ± 0.73 |
| Axons | ||||||
| Length (mm) | 4.02 ± 1.6 | 4.81 ± 3.0 | 5.20 ± 1.83 | 5.26 ± 2.21 | 9.23 ± 2.95 | 10.1 ± 4.49 |
| Branch number | 28.0 ± 15.5 | 27.5 ± 19.3 | 59.8 ± 19.1 | 53.2 ± 25.1 | 87.8 ± 28.4 | 80.7 ± 37.4 |
| Varicosity number | 396 ± 215 | 481 ± 302 | 771 ± 422 | 629 ± 293 | 1167 ± 571 | 1111 ± 437 |
| Varicosity density (number/100 μm) | 9.38 ± 3.70 | 9.97 ± 3.70 | 14.27 ± 3.83 | 11.75 ± 2.27 | 12.02 ± 3.45 | 10.86 ± 1.10 |
F1-a
Measures are from terminal order dendritic segments, n = 6. Six neurons were reconstructed in both the experimental and control groups. Data are expressed as mean ± SD.
*p < 0.05.
**p < 0.01.
***p < 0.001.