Table 2.
Localization of sequence encoding with a small keyboard
| Anatomic location | Talairach coordinates (mm) | Group A Mean rCBF (SD) | Uncorrected p value | ||||
|---|---|---|---|---|---|---|---|
| X | Y | Z | Sequence 1 | Sequence 2 | Sequence 3 | RM ANOVA | |
| L VL thalamus | −10 | −12 | 4 | 61.1 (3.2) | 63.8 (3.8) | 64.2 (3.3) | 0.005*, *** |
| L postcentral sulcus (40) | −50 | −11 | 28 | 59.9 (4.8) | 60.8 (3.0) | 62.1 (4.2) | 0.005*** |
| L angular gyrus (39) | −39 | −63 | 33 | 56.5 (4.7) | 57.8 (4.2) | 58.3 (4.3) | 0.005 |
| L anterior cingulate (32) | −14 | 21 | 41 | 57.7 (3.2) | 61.1 (4.2) | 61.4 (2.8) | 0.005*, *** |
| L cingulate gyrus (24/23) | −1 | −28 | 33 | 61.0 (4.6) | 63.4 (5.0) | 63.0 (5.3) | 0.01** |
| L superior parietal lobule (7) | −21 | −49 | 52 | 53.6 (3.4) | 54.6 (2.5) | 54.8 (3.9) | 0.005* |
| L central sulcus (4,3,1,2) | −20 | −23 | 57 | 51.3 (2.9) | 52.8 (3.3) | 53.1 (3.0) | 0.01 |
| R dorsal frontal gyrus (6) “SMA” | 4 | −5 | 67 | 66.8 (4.8) | 69.6 (5.4) | 69.6 (6.8) | 0.01** |
Locations were determined by repeated measures ANOVA and linear contrasts across scans 3–5 of group A. All sites with longitudinal increases of rCBF during sequence encoding are included. None of these sites showed significant increases in the control group, who were exposed to random stimuli during these scans. Mean rCBF values are in units of milliliters per minute/100 gm of tissue. Anatomic locations in parentheses are Brodmann’s areas according to the atlas of Talairach and Tournoux (1988).
*Significant at p < 0.05 after correcting for multiple comparisons.
**Significant group–task interaction (p < 0.05).
***Significant group–task interaction (p < 0.01).