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. 1998 Mar 15;18(6):1953–1962. doi: 10.1523/JNEUROSCI.18-06-01953.1998

Fig. 3.

Fig. 3.

MAG-deficient nerves have reduced neurofilament spacing. A, B, In electron micrographs, neurofilaments (arrowheads) appear as 10-nm-thick structures from which sidearms (arrows) extend. Compared with myelinated axons in 9-month-old control nerves (A), neurofilaments are spaced closer together in 9-month-old MAG-deficient myelinated axons (B). Scale bar, 0.1 μm. C–E, Compared with myelinated axons in control nerves, the neurofilament nearest neighbor distance in myelinated axons in MAG-deficient nerves was significantly reduced at P35 (C), 3 months (D), and 9 months (E). Statistical analysis by Student’s t test analysis;n = number of neurofilaments analyzed.F, Neurofilament spacing in unmyelinated axons was similar in control and MAG-deficient nerves from 9-month-old mice;n = number of neurofilaments analyzed.