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Quantitative analysis of Wallerian degeneration in sciatic nerve of MAG-deficient and control mice
| Age | ||||||
|---|---|---|---|---|---|---|
| 7 and 14 d | 35 d | 3 month | 6 month | 9 month | 16 month | |
| MAG+/+ | 0 | 0 | 0 | 0 | 0 | 0.5 ± 0.6 |
| MAG−/− | 0 | 2.0 ± 0.8* | 4.2 ± 1.3* | 4.3 ± 0.5** | 5.3 ± 1.5** | 5.4 ± 2.7* |
Epon sections (1-μm-thick) of sciatic nerves from four MAG+/+ and four MAG−/− mice were analyzed at each age. Numbers represent mean ± SD of degenerating myelinated internodes per total nerve cross section.
*p < 0.01; **p < 0.001.
