Table 2.
Morphological analysis of sciatic nerve myelin sheaths
Genotype | Age (months) | Processes | Pathology (%) |
---|---|---|---|
Wild type | |||
Animal 1 | 1 | 280 | 2.1 |
Animal 2 | 8 | 214 | 3.3 |
Animal 3 | 8 | 299 | 2.3 |
Animal 4 | 8 | 348 | 2.9 |
Animal 5 | 12 | 230 | 4.8 |
Animal 6 | 12 | 198 | 3.0 |
Total | 1569 | 3.1 ± 0.17 | |
L-MAGtrun | |||
Animal 1 | 1 | 308 | 1.3 |
Animal 2 | 1 | 305 | 2.6 |
Animal 3 | 8 | 265 | 6.0 |
Animal 4 | 8 | 184 | 4.4 |
Animal 5 | 12 | 282 | 2.8 |
Animal 6 | 16 | 289 | 3.5 |
Animal 7 | 16 | 202 | 2.5 |
Animal 8 | 16 | 321 | 3.7 |
Animal 9 | 16 | 285 | 5.3 |
Total | 2541 | 3.6 ± 0.14 |
Randomly selected sheaths of sciatic nerves 5 mm distal to the sciatic notch were analyzed for the presence of multiple wraps, lack of compaction, and redundant myelin as described in Table 1. Electron micrographs at 5000× were examined. Data are presented as mean ± SE and were analyzed using the Student t test. No significant difference was found.