Fig. 2.
A, Left, Prevalence of subtypes of thin myelinated (Aδ−) cutaneous fibers in WT and NT4−/− mice that is significantly different (p < 0.001, χ2 test). Right, Histograms illustrate representative examples of the mechanical response properties of a D-hair receptor (DH, top) and an AM nociceptor (AM, bottom). B, Stimulus–response functions of D-hair receptors to constant force stimuli. The stimulus–response functions of the two D-hair receptors found in NT4−/− mice were reduced compared with WT mice (F(1,103) = 6.21; p < 0.05, ANOVA) and closely resemble the stimulus–response functions of D-hairs in p75−/− mice (p75−/− data from Stucky and Koltzenburg, 1997).