Catecholaminergic neurons accumulate 5-HT in P7 MAOA knock-outs. Coronal section through the SN–VTA complex (A, C) and the LC (B,D) were double immunostained with antibodies to 5-HT (A, B) and TH (C,D). As indicated by the arrowheads, almost all TH-positive neurons contain 5-HT immunolabeling. The varicose 5-HT-positive terminal network contains no TH immunolabeling (arrow). Scale bar (in D):A, C, 140 μm; B,D, 50 μm.