Fig. 5.
Reduction of FNE-induced currents by TTX and bicuculline. A, FNE (50 μm)-induced synaptic currents were reduced by TTX (1 μm) application. The solution always contained CNQX/APV. B, Both spontaneously occurring and FNE (50 μm)-induced outward currents were completely suppressed by simultaneous application of the GABAA receptor antagonist bicuculline (100 μm). The solution always contained CNQX/APV.C, Dose dependency of FNE (10–50 μm)-induced increase of IPSC frequency and its reduction by TTX. The data are percentages of the control value. The error bars represent SEM. The numbers of cells examined are given inparentheses. The effects of FNE (50 μm) in the presence or absence of TTX (0.3 μm) were compared using Mann–Whitney U test. **p < 0.01.