Fig. 6.

Pharmacological characterization of NA-induced GABAergic currents. A, An α1 antagonist prazosin (3 μm) reduced the NA (10 μm)-induced increase of amplitude and frequency of GABAergic currents in a layer V pyramidal cell. B, Summary of the effects of adrenergic agonists on spontaneous IPSC frequency and of adrenergic antagonist on the NA-induced increase of IPSC frequency in a CNQX/APV-containing solution. Pheny, Phenylephrine (α₁-adrenergic agonist);Cloni, clonidine (α₂-adrenergic agonist);Isopro, isoproterenol (β-adrenergic agonist). The data for agonists (NA, Pheny, Cloni, and Isopro) are normalized as a percentage of control values. The error bars represent SEM. The numbers of cells examined are given in parentheses. The effects of NA (10 μm) in the presence or absence of prazosin (Prazo, α₁-adrenergic antagonist) and yohimbine (Yohim, α₂-adrenergic antagonist) were compared using Mann–Whitney U test. *p < 0.01.