Table 1.
Actions of noradrenaline (NA) or 6-fluoronorepinephrine (FNE) on identified GABAergic cell types
| GABA cell type | n | Cell characteristics | Adrenergic responses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Resting potential (mV) | Input resistance (MΩ) | Cross-sectional somatic | NA (10–50 μm) (number of cells) | FNE (10–50 μm) (number of cells) | Spike firing1-a (firing cells/ total in CNQX/APV) | ||||||
| Area (μm2) | Longest extent (μm) | Depo | Hyper/ Depo | Depo | Hyper/Depo | Hyper | |||||
| FS cells | 36 | −70.1 ± 4.9 | 144 ± 38 | 151 ± 37 | 17.1 ± 2.8 | 9 | 27 | 0/28 (0%) | |||
| LS cells | 7 | −62.3 ± 4.7 | 184 ± 51 | 144 ± 60 | 16.2 ± 3.6 | 6 | 1 | 0/6 (0%) | |||
| SOM RSNP cells | 21 | −53.4 ± 3.2 | 332 ± 100 | 202 ± 60 | 19.7 ± 3.3 | 4 | 1 | 15 | 1 | 12/13 (92%) | |
| SOM BSNP cells | 3 | −50.7 ± 4.9 | 400 ± 39 | 176 ± 96 | 18.3 ± 3.1 | 2 | 1 | ||||
| CCK RSNP cells | 22 | −52.6 ± 27.0 | 360 ± 102 | 250 ± 59 | 22.8 ± 4.2 | 7 | 1 | 6 | 6 | 2 | 6/15 (40%) |
| CCK BSNP cells | 4 | −58.0 ± 2.7 | 697 ± 284 | 225 ± 43 | 22.4 ± 4.2 | 4 | 2/4 (50%) | ||||
The solution contained CNQX/APV, TTX or both. Data are mean ± SD. n, Number of cells; Depo, depolarization; Hyper/Depo, hyperpolarization followed by depolarization; Hyper, hyperpolarization; FS, fast-spiking; LS, late-spiking; RSNP, regular-spiking nonpyramidal; BSNP, burst-spiking nonpyramidal; SOM, somatostatin; CCK, cholecystokinin.
F1-a
Proportion of cells that fired spikes in response to NA or FNE application in a solution containing CNQX/APV but not TTX.