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. 1998 Sep 1;18(17):7008–7014. doi: 10.1523/JNEUROSCI.18-17-07008.1998

Fig. 2.

Fig. 2.

l-NMA reduces the PGE2-induced potentiation of TTX-R INa. TTX-R INa was monitored by test pulses given every 20 sec. Voltage of the test pulse (−20 to −5 mV) was selected for each neuron to give an approximately half-maximal current amplitude. One hundred micromolar d-NMA or l-NMA was included in the bath for 15 min before exposure to 1 μm PGE2. PGE2 typically causes a potentiation of TTX-R INa in approximately half of cells tested (Gold et al., 1996a,b). Experiments were alternated between using the active and inactive enantiomers of the NOS inhibitor, and data from all neurons were used, including those in which the current was not affected by PGE2. Peak current amplitudes were normalized to mean of the baseline measurements.