Fig. 7.

Expression of perch connexins induces the formation of both homotypic and heterotypic intercellular channels. Oocytes pretreated with an oligonucleotide antisense to a sequence within the coding region of Xenopus Cx38 were injected with either connexin cRNAs or water (w) and paired for 24–48 hr before measuring junctional conductance by dual voltage clamp. Cells received similar amounts of Cx34.7 (34.7) and Cx35 (35) cRNAs. Junctional conductances increased approximately twofold between 24 and 48 hr for homotypic pairs, but the heterotypic pairing showed little change. Values are mean ± SEM of 8–11 oocyte pairs.