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. 1998 Oct 1;18(19):7768–7778. doi: 10.1523/JNEUROSCI.18-19-07768.1998

Fig. 6.

Fig. 6.

Ischemia increases dentate neurogenesis in ischemic-tolerant animals. Animals received 2 (B) or 5 (C) min of global ischemia or 2 min of ischemic preconditioning followed by 5 min of global ischemia (D) compared with untreated control (A). Hippocampal sections were obtained 8 d after the sham operation or the last ischemic insult and analyzed by NeuN immunohistochemistry. Approximately 50% of the preconditioned gerbils showed intact CA1 morphology. Only these animals that lacked CA1 damage were analyzed for dentate neurogenesis. Scale bar, 200 μm.E, Animals were subjected to 2 (n = 8) or 5 (n = 6) min of ischemia. TheTolerant group of animals was subjected to 2 min of ischemic preconditioning, followed by 5 min of ischemia 3 d later (n = 9). BrdU was given 8 d after ischemia, and the animals were killed 1 d later. BrdU was given 24 hr before the control animal was killed (Control) (n = 10). Data shown are mean ± SE. *p < 0.05 compared with control.