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. 1998 Aug 1;18(15):5777–5788. doi: 10.1523/JNEUROSCI.18-15-05777.1998

Table 2.

Comparison between neural stem cells, pre-progenitors, and O-2A progenitor properties in vitro

	Embryonic Neural Stem Cells	Neonatal Brain Pre-progenitors	CNS O-2A Progenitors
Shape in phase microscope	Flat or bipolar, can grow in spheres	Small round, growing in clusters/spheres	Bipolar with long processes and motile
Antigenic phenotype	Nestin+	PSA-NCAM and nestin+ A2B5−, GD3−	Progressive loss of PSA-NCAM and nestin, but A2B5+, GD3+
Mitogenic growth factors (GF)	FGF2, EGF^2-a	FGF2, PDGF, EGF	FGF2, PDGF, NT3, IGF-1
Thyroid hormone effects	Can induce an OL fate^2-b	Enhances FGF2-mediated growth	Limits proliferation and triggers myelin gene expression^2-c
Differentiation potential	Neurons, astrocytes, and OL	OL and astrocytes	OL and type 2 astrocytes

OL, Oligodendrocyte.

^F2-a

Weiss et al., 1996.

^F2-b

Johe et al., 1996.

^F2-c

Barres et al., 1994; Hudson et al., 1996.