Table 3.

Neurological testing of Igf^−/−mice and wild-type littermates

	Wild-type	Igf−/−	p
Rotorod performance	227.7  ± 24.1	156.6  ± 19.0	<0.05
	(n = 14)	(n = 16)
Wire-hang latencies	136.4  ± 44.0	229.5  ± 31.2	NS
	(n =  9)	(n = 11)

Values are mean ± SEM of number of animals indicated for each group. The rotorod performance tests the ability of mice to maintain balance on a rotating cylinder. Mice that did not fall or cling during the 300 sec trial period were given a score of 300. Wire-hang latency measures the ability of mice to hang upside down from a wire screen. Mice that did not fall during the 300 sec trial period were given a score of 300. The data were compared using ANOVA followed by Bonferroni-corrected t tests. NS, Not significant.