Table 1.

Spontaneous remyelination in PBS-treated SJL/J mice after lysolecithin injection in the spinal cord

Time after lysolecithin injection	Remyelinated axonsa,b (No./mm2 lesion)	G ratio: myelin sheathc,d,e thickness/axon diameter (%)
2 weeks	721  ± 117  (6)	6.7  ± 0.6  (33)
3 weeks	1875  ± 323  (5)	9.6  ± 0.4  (92)
5 weeks	4312  ± 1282  (6)	12.8  ± 0.7  (93)

^F1-aNumber in parentheses shows the number of mice examined; data expressed as mean ± SEM.

^F1-bBy ANOVA on Ranks, the number of remyelinated axons was increased significantly from 2 weeks to 5 weeks (p < 0.05).

^F1-cNumber in parentheses indicates the number of axons remyelinated by oligodendrocytes studied by electron microscopy; data expressed as mean ± SEM.

^F1-dBy ANOVA on ranks, the ratio of myelin sheath thickness to axon diameter was increased statistically from 2 weeks to 5 weeks (p < 0.0001). All pairwise multiple comparison procedures (Dunn’s method) revealed significant differences (p < 0.05) when comparing G ratios between 2 week, 3 week, and 5 week groups.

^F1-eNormal myelinated axons (n = 127) produced a G-ratio of 18.1 ± 0.4.