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. 1998 Apr 1;18(7):2550–2559. doi: 10.1523/JNEUROSCI.18-07-02550.1998

Fig. 3.

Fig. 3.

GABA evokes inhibitory responses in cultured hippocampal neurons. A, Cell-attached patch recording of action potential discharges in a cultured neuron. Spontaneous activity (top 4 traces) is inhibited by exposure of the cell to 10 μm GABA applied via an adjacent pressure pipette (middle 4 traces). Spontaneous activity recovers thereafter. Bottom traces, Culture treated with estradiol for 24 hr. Patch pipette contained extracellular recording medium. B, C, Similar postsynaptic responses to GABA in control and estradiol-treated cultures.B, GABA-induced currents in control (top) and estradiol-treated (bottom) neurons. Cells were held at −60, −30, 0, and +30 mV. Patch pipette contained CsCl.C, Averaged IV curves showing similar responses to GABA of eight control (Ct) and six estradiol (Est)-treated cells for 24 hr.